Thomas Jane almost was Rick Grimes.
Rutina Wesley was rumored for the role of Michonne before Danai Gurira.
Laurie Holden originally auditioned for the role of Lori Grimes. Both characters, Andrea Harrison and Lori Grimes both died in season 3.
John Hawkes turned down the role of the Governor.
In the first two seasons, Andrew Lincoln, Jon Bernthal, and Sarah Wayne Callies are the only cast members to have been credited alongside images of themselves in the opening credits.